HPE ProLiant ML350 Gen12
4U Tower Server · Intel® Xeon® 6
Are you looking for a robust, flexible tower server for your SMB and remote office environments? The HPE ProLiant Compute ML350 Gen12 is a 4U two-socket tower server with optional rackable chassis, delivering exceptional compute performance, enterprise-grade security, and expandability for a wide range of demanding workloads.
Are you looking for a flexible and powerful tower server for your SMB and remote offices?
The HPE ProLiant Compute ML350 Gen12 is a robust 4U two-socket tower server with optional rackable chassis, delivering exceptional compute performance, security, reliability, and expandability for various environments. Powered by Intel® Xeon® 6700/6500 P-series processors with up to 86 P-cores per socket (172 per server) and up to 8 TB DDR5 6400 memory, the ML350 Gen12 fulfils a wide range of demanding workloads including IT infrastructure, data management, VDI, and ERP/CRM.
The HPE ProLiant Compute ML350 Gen12 is engineered for your future, with next-level security anchored by a silicon root of trust, optimised performance across PCIe Gen5 expansion, and automated, AI-driven productivity through HPE iLO 7 and Compute Ops Management.
What’s New
- Intel® Xeon® 6700 and 6500 series with P-cores; up to 86 P-cores per socket (172 P-cores per server), 350W TDP; increased memory bandwidth to 6400 MT/s, up to 8 TB DDR5 memory capacity.
- Supports ultra-high SSD performance with NVMe x4 and EDSFF drive cages, and mixed dual-mode LFF and tri-mode SFF drive cages as a hybrid storage optimisation solution.
- Provides up to 24 NVMe drives with PCIe Gen5 x2 bandwidth for maximum storage capacity with balanced performance.
- HPE Integrated Lights-Out 7 (iLO 7) with quantum-resistant algorithms (PQC) and FIPS 140-3 Level 3 certification for seamless, secure management from anywhere.
- Supports new NS204i-u V2 as a hot-pluggable, high-availability, RAID1-protected M.2 NVMe boot option.
- Supports NVIDIA® L4 24GB Accelerator.
Next-Level Security, Chip to Cloud
From silicon to software, from factory to cloud, and from generation to generation, HPE ProLiant Compute Gen12 is engineered with a fundamental security approach to defend against increasingly complex threats through an uncompromising commitment to constant security advancements.
The HPE Silicon Root of Trust establishes a zero-trust security framework at the silicon level to ensure firmware integrity. Continuous protection detects compromised servers and prevents them from booting if malicious code is found. HPE ProLiant Compute servers provide automated recovery from a security event, including restoration of validated firmware and facilitating recovery of operating system, application, and data connections — providing the fastest path to bring a server back online.
HPE iLO 7 supports quantum-resistant (PQC) algorithms and signs HPE ProLiant Compute Gen12 firmware with algorithms approved by CNSA 2.0, enhancing resilience against potential future attacks by quantum computers.
Optimised Performance for Your Workloads: Accelerated, Open, and Efficient
An excellent choice for compute and data-storage-demanding workloads — including AI, machine learning, telco, and DB analytics — requiring high core count, GPU capabilities, and network and I/O bandwidth.
Powered by Intel® Xeon® 6700P/6500P-series processors supporting up to 86 P-cores per socket at 350W TDP. Enjoy advanced data transfer rates from the PCIe Gen5 serial expansion bus, with up to 4 x16 PCIe Gen5 and 2 x16 OCP slots to improve I/O throughput and reduce latency.
Utilise 32 DIMM slots for up to 8 TB DDR5 memory with increased memory bandwidth, supporting the widest range of memory-intensive enterprise workloads.
Intuitive Cloud Operating Experience: Simple, Self-service, and Automated
HPE ProLiant Compute ML350 Gen12 servers are engineered for your hybrid world, simplifying the way you control your business's compute — from edge to cloud — with a cloud operating experience. Transform business operations and pivot your team from reactive to proactive with global visibility and insight through a self-service console.
Automate tasks for efficiency in deployment, instant scalability, and seamless, simplified support and lifecycle management — reducing tasks and shortening maintenance windows. Whether purchased as physical servers or consumed as-a-service via HPE GreenLake, these experiences are built into every Gen12 server.
Industry-leading Services and Ease of Deployment
The HPE ProLiant Compute ML350 Gen12 server comes with a complete set of HPE Services, delivering confidence, reducing risk, and helping customers realise agility and stability. HPE Services simplify all stages of the IT journey — Advisory and Transformation Services professionals understand your challenges and design an effective solution, while Professional Services enable rapid deployment and Operational Services provide ongoing support.
Services provided under Operational Services include: HPE Flexible Capacity, HPE Datacenter Care, HPE Infrastructure Automation, HPE Campus Care, HPE Proactive Services, and multi-vendor coverage. Benefit from real-time operational feedback on server performance plus recommendations for fine-tuning BIOS settings to customise for changing business needs.
*Intel® and Intel® Xeon® are trademarks of Intel Corporation in the U.S. and other countries. NVIDIA® is a trademark and/or registered trademark of NVIDIA Corporation in the U.S. and other countries. All other third-party trademark(s) is/are property of their respective owner(s). Specifications and availability are subject to change without notice.

