HPE ProLiant DL380a Gen12
4U Accelerator-Optimized Rack Server · Intel® Xeon® 6

HPE Products

HPE ProLiant DL380a Gen12 Servers

HPE ProLiant DL380a Gen12 – 4U Accelerator-Optimized Rack Server, Intel® Xeon® 6, up to 8 Double-Wide GPUs, up to 8TB DDR5, PCIe Gen5

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Overview:

Are you looking for a server with advanced GPU scalability to accelerate AI inferencing for your largest workloads?

The HPE ProLiant DL380a Gen12 is engineered with an ultra-scalable architecture to deliver next-generation AI performance for your enterprise needs — the “a” stands for accelerator optimized. This 4U two-socket rack server pairs the latest Intel® Xeon® 6 processors with dense GPU acceleration, blazing-fast memory bandwidth, and PCIe Gen5 I/O to accelerate AI inferencing for large workloads with enterprise-grade reliability and industry-leading security.

What’s New

Intel® Xeon® 6 processors with up to 144 cores across two sockets.
Support for up to 8 double-wide or 16 single-wide GPUs in a single 4U chassis for intensive compute acceleration.
Up to 8 TB of DDR5 memory across 32 DIMM slots for memory-hungry AI and analytics workloads.
High-speed PCIe Gen5 with up to 6 x16 slots and 2 OCP 3.0 slots to improve I/O throughput and reduce latency.
HPE Integrated Lights-Out 7 (iLO 7) management and HPE Compute Ops Management for cloud-based, AI-informed operations.

Features:

Optimised Performance for AI Workloads

An excellent choice for AI, compute, and graphics-intensive workloads requiring maximum GPU density, core count, and I/O bandwidth. With up to 8 double-wide GPUs, up to 144 Intel® Xeon® 6 cores, up to 8 TB of DDR5, and PCIe Gen5 connectivity, the DL380a Gen12 is built to accelerate AI inferencing for large workloads.

Next-Level Security, Chip to Cloud

The HPE Silicon Root of Trust establishes a zero-trust security framework at the silicon level to ensure firmware integrity, continuously detecting compromised servers and preventing them from booting if malicious code is found. HPE ProLiant Compute servers provide automated recovery from a security event, including restoration of validated firmware, and facilitating recovery of operating system, application and data connections — providing the fastest path to bring a server back online and into normal operations.

HPE iLO 7 supports quantum-resistant (PQC) algorithms and signs HPE ProLiant Compute Gen12 firmware with algorithms approved by CNSA 2.0, enhancing resilience against potential future attacks by quantum computers.

Automated, AI-Driven Operations

Simplify and secure server management from edge to cloud with HPE Compute Ops Management, an as-a-service experience that delivers global visibility, AI-informed insights, and automation for deployment, scaling, and lifecycle management. Monitor and maintain all servers within your distributed environment with actionable dashboards that provide a clear view of up-to-date server health across all locations.

Available as a standalone purchase or as a service via HPE GreenLake.

Technical Specifications:

HPE ProLiant DL380a Gen12 Server Specifications
Form factor	4U Rack, Two-Socket (2P)
Processors	Intel® Xeon® 6, up to 144 cores (2 CPUs)
Memory	32 DIMM slots, up to 8 TB DDR5 (up to 6400 MT/s at 1 DIMM per channel)
GPU support	Up to 8 double-wide or 16 single-wide GPUs
Storage	Up to 8 SFF NVMe (U.3) or 16 EDSFF E3.S drives; HPE NS204i-u v2 boot device option
Expansion slots	PCIe Gen5 — up to 6 x16 slots plus 2 OCP 3.0 slots
Cooling	Air-cooled with hot-plug fan assemblies
Infrastructure management	HPE iLO 7, HPE Compute Ops Management, Silicon Root of Trust

GPU model compatibility (e.g. NVIDIA L4, L40S, H100 NVL, H200, RTX PRO 6000 Blackwell) varies by configuration; contact us to confirm the accelerators certified for your build.

Documentation:

Download the HPE ProLiant Compute DL380a Gen12 QuickSpecs (HPE.com)

*Intel® and Intel® Xeon® are trademarks of Intel Corporation in the U.S. and other countries. NVIDIA and related GPU product names are trademarks and/or registered trademarks of NVIDIA Corporation. All other third-party trademark(s) is/are property of their respective owner(s). Specifications and availability are subject to change.

Pricing Notes: