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HPE ProLiant ML350 Gen11 5416S Server
16-Core 2.00GHz 64GB RAM 2x480GB SSD

HPE ProLiant ML350 Gen11 server
HPE Gen11 ML350 server - Front HPE Gen11 ML350 server - Left HPE Gen11 ML350 server - Rear HPE Gen11 ML350 server - Open HPE Gen11 ML350 server - Open2

HPE Products
HPE ProLiant ML350 Gen11 Servers
HPE ProLiant ML350 Gen11 5416S 16-Core 64GB RAM MR408i-o Smart Array Controller 8SFF 2x480GB SSD 2x800W Redundant Power Supply AMS Server
#P69313-005
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Overview:

Are you looking for a robust and flexible tower optimized server for your SMB and remote offices?

The HPE ProLiant ML350 Gen11 is a powerful 2P tower server with optional rackable chassis for various environments, and delivers exceptional compute performance, security, reliability, and expandability.

Powered by 4th and 5th Gen Intel® Xeon® Scalable Processors up to 64 cores1, up to 8 TB DDR5, PCIe Gen5, enhanced I/O and GPU support, and EDSFF storage, the HPE ProLiant ML350 Gen11 server fulfills a wide range of demanding workloads.

The silicon root of trust anchors the server firmware to an HPE-exclusive ASIC, creating a fingerprint for the 4th and 5th Gen Intel Xeon Scalable processors that must be matched exactly before the server will boot.

The HPE ProLiant ML350 Gen11 server is an excellent choice for diverse workloads such as IT infrastructure, Data Management, VDI, ERP/CRM. Scale and adapt to any environment with this server and accelerate your growing business.

What’s New

  • Powered by 4th and 5th Gen Intel® Xeon® Scalable Processors that support up to 64 cores1 (128 cores per server), 350W TDP.
  • Increased memory bandwidth to 5600 MT/s2, performance and lower power requirements with up to 8 TB DDR5 memory capacity with 32 DIMM slots.
  • Advanced data transfer rates from the PCIe Gen5 serial expansion bus, support up to 10 standard PCIe Gen5 slots and 2 OCP 3.0 slots3.
  • Includes HPE Integrated Lights-Out 6 (iLO 6) server management software that enables you to securely configure, monitor, and update your HPE ProLiant Gen11 servers seamlessly from anywhere.
  • Supports hot-pluggable, high-availability, RAID1 protected M.2 NVMe boot option.
  • Supports new EDSFF E3.S NVMe form factor to enable higher-density servers and storage systems, optimization of PCIe lanes from CPUs, and ultra-high SSD performance.

Notes:
1Support up to 64-core with 5th Gen Intel processor and 60-core with 4th Gen Intel processor
2DDR5 5600 MT/s memory is limited to support with 5th Gen Intel processors. The maximum memory speed is a function of the memory type, memory configuration, and processor model.
3OCP and two tertiary riser PCIe slots are shared with 3 internal MICO connectors.

Features:

Intuitive Cloud Operating Experience: Simple, Self-service, and Automated

HPE ProLiant ML350 Gen11 servers are engineered for your hybrid world. The new ProLiant Gen11 servers simplify the way you control your business’s compute—from edge to cloud—with a cloud operating experience.

Transform business operations and pivot your team from reactive to proactive with global visibility and insight through a self-service console.

Automate tasks for efficiency in deployment, instant scalability, and seamless, simplified support and lifecycle management reducing tasks and shortening maintenance windows.

These experiences are engineered and built into all HPE ProLiant Gen11 servers, whether purchased as physical servers or consume as-a-service using HPE GreenLake as your compute and storage demands grow.

Simplify and secure server management from edge to cloud with HPE GreenLake for Compute Ops Management. HPE GreenLake for Compute Ops Management is an as-a-service compute management experience that delivers greater simplicity, agility, and speed across your entire compute landscape, globally.

Trusted Security by Design: Uncompromising, Fundamental, and Protected

HPE ProLiant ML350 Gen11 server uses the silicon root of trust to anchor the firmware of an HPE ASIC, creating an immutable fingerprint for the Intel Processor that must be matched exactly before the server will boot. This verifies that malicious code is contained, and healthy servers are protected.

HPE ProLiant Gen11 servers continuously protect healthy servers at the edge by providing rapid detection of security-compromised servers, even to the point of not allowing them to boot if it identifies and contains malicious code, with IDevID certificates installed by default.

HPE ProLiant Gen11 servers provide automated recovery from a security event, including restoration of validated firmware, and facilitating recovery of the operating system, application, data connections, and providing a fast path to bring a server back online and into normal operations.

From silicon to software, from factory to cloud, and from generation to generation, HPE ProLiant Gen11 is engineered with a fundamental security approach to defend against increasingly complex threats through an uncompromising commitment to constant security advancements that are built into our DNA.

Optimized Performance for your Workloads: Accelerated, Open, and Efficient

The HPE ProLiant ML350 Gen11 server is an excellent choice for Compute and data storage demanding workloads (AI, ML, telco, DB analytics,) requiring high core count, GPU capabilities, and network and I/O bandwidth.

Harness major compute performance. The HPE ProLiant ML350 Gen11 server is powered by 4th and 5th Gen Intel® Xeon® Scalable Processors that support up to 64 cores1 (128 cores per server) at 350W TDP.

Enjoy advanced data transfer rates and higher network speeds from the PCIe Gen5 serial expansion bus, with up to 4 x16 PCIe Gen5 and 2 x16 OCP slots to improve I/O throughput and reduce latency.

Utilize 32 DIMM channels for up to 8 TB DDR5 memory with increased memory bandwidth and performance, and lower power requirements.

Industry-leading Services and Ease of Deployment

The HPE ProLiant ML350 Gen11 server comes with a complete set of HPE Services, delivering confidence, reducing risk, and helping customers realize agility and stability.

HPE Services simplify all stages of the IT journey. Advisory and Transformation Services professionals understand customer challenges and design an effective solution. Professional Services enable rapid deployment of solutions and Operational Services provide ongoing support.

Services provided under Operational Services include: HPE Flexible Capacity, HPE Datacenter Care, HPE Infrastructure Automation, HPE Campus Care, HPE Proactive Services and multi-vendor coverage.

HPE IT investment solutions help you transform to a digital business with IT economics that align to your business goals.

Benefit from real-time operational feedback on server performance plus recommendations for fine-tuning BIOS settings to customize for changing business needs.

Technical Specifications:


HPE ProLiant ML350 Gen11 5416S 16-core 1P 64GB-R MR408i-o 8SFF 2x480GB SSD 2x800W RPS AMS Server Specifications
Detailed product description HPE ProLiant ML350 Gen11 8 SFF server with one Intel® Xeon® Gold 5416S processor, two 32 GB DDR5 RDIMM memory, HPE MR408i-o storage controller, two 480 GB SSD, and two HPE 800W Flex Slot Power Supply
Product Number P69313-005
Processor name Intel® Xeon® Gold 5416S (16 core, 2.00 GHz, 30 MB L3, 150W)
Processor number 1 processor included
Processor core available 16 core
Processor cache 30 MB L3
Processor speed 2.0 GHz
Power supply type 2x HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
Expansion slots Default with 4 x8 PCIe 5.0 slots. Refer to the QuickSpecs for more detail.
Memory type HPE DDR5 Smart Memory
Included hard drives 2x 480GB SATA SSD
Optical drive type Optional. None ship standard.
System fan features Default with 8 fans with redundancy functionality to provide advanced cooling in heavier configurations.
Network controller Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE
Storage controller HPE MR408i-o Gen11 x8 Lanes 4GB Cache OCP SPDM Storage Controller
DIMM capacity 64 GB RDIMM
Infrastructure management HPE iLO Standard with Intelligent Provisioning (embedded), HPE OneView Standard (requires download)
HPE iLO Advanced, and HPE OneView Advanced (require licenses) Compute Ops Management Software
Warranty Server Warranty includes three years of parts, three years of labor, and three years of on-site support coverage.

Hardware Specs:

HPE ProLiant ML350 Gen11 server

Front View
Front View – LFF chassis with optional Gen11 4LFF HDD Cage Kits shown (Rack mode)

1 Optical drive bay
2 Media bay filler panel
3 Serial number/iLO information pull tab
4 Box 3: Default drive cage for 4LFF
5 Box2: Optional drive cage for 8SFF/4LFF
6 Box1: Optional drive cage for 8SFF/4LFF, or USB RDX docking station.
7 DisplayPort 1.1a
8 USB 3.2 Gen1 port
9 iLO service port
10 UID button/LED
11 NIC status LED
12 Health LED
13 Power on/Standby button and system power LED

Front View
Front View – SFF chassis with optional Gen11 8SFF HDD Cage Kits shown (Tower mode)

1 DisplayPort 1.1a
2 USB 3.2 Gen1 port
3 iLO service port
4 UID button/LED
5 NIC status LED
6 Health LED
7 Power on/Standby button and system power LED
8 Optical drive bay
9 Media bay filler panel
10 Serial number/iLO information pull tab
11 Box1: Optional drive cage for 8SFF
12 Box2: Optional drive cage for 8SFF
13 Box 3: Default drive cage for 8SFF

Internal View
Internal View – with optional 2nd CPU, OCP NIC adapter and NS204i-u shown

1 CPU Socket 11 & 22
2 Dual USB port (Stacked, Top: USB 3.2 Gen1 port, Bottom: USB 2.0 port)
3 Megacell battery holder (Under)
4 HPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device (Optional)
5 Secondary riser connector
6 Tertiary riser sideband connector
7 Serial port cable connector
8 Slot 15 OCP 2 (Optional for NIC adapter)
9 HPE NS204i-u power connector
10 Primary riser connector
11 Slot 14 OCP 1 (Optional for OROC/NIC adapter)

Rear View
Rear View – With HPE Flex Slot RPS shown.

1 Kensington security slot
2 PCIe Slots 9-10 (Optional tertiary riser, 2nd processor required)
3 Flexible Slot power supply 1
4 Flexible Slot power supply 2 (Optional)
5 VGA Port
7 Serial port (Optional)
8 iLO management port
9 USB 3.2 Gen 1 ports x2
10 Slot 14 OCP 1 (Optional for OROC/NIC adapter)
11 PCIe Slots 1-4 (Primary riser)
12 Padlock eye
14 HPE NS204i-u Gen11 NVMe Hot Plug Boot Optimized Storage Device (Optional)

Documentation:

Download the HPE ProLiant ML350 Gen11 5416S 16-core 1P 64GB-R MR408i-o 8SFF 2x480GB SSD 2x800W RPS AMS Server Data Sheet (.PDF)

Download the HPE ProLiant ML350 Gen11 server Datasheet (.PDF)

Download the HPE ProLiant ML350 Gen11 server Quick Specs (.PDF)

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*Intel® and Intel® Xeon® are trademarks of Intel Corporation or its subsidiaries. All third-party marks are property of their respective owners.

Pricing Notes:

HPE Products
HPE ProLiant ML350 Gen11 Servers
HPE ProLiant ML350 Gen11 5416S 16-Core 64GB RAM MR408i-o Smart Array Controller 8SFF 2x480GB SSD 2x800W Redundant Power Supply AMS Server
#P69313-005
Our Price: Request a Quote
HPE Tech Care Smart Choice Services
HPE 3Year Tech Care Basic ML350 Gen11 Smart Choice Service
#H44ZVE
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HPE 5Year Tech Care Basic ML350 Gen11 Smart Choice Service
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HPE 3Year Tech Care Essential ML350 Gen11 Smart Choice Service
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HPE 5Year Tech Care Essential ML350 Gen11 Smart Choice Service
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HPE iLO Advanced 1-server License with Support on iLO Licensed Features
HPE iLO Advanced 1-server License with 3yr Support on iLO Licensed Features
#BD505A
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HPE iLO Advanced 1-server License with 1yr Support on iLO Licensed Features
#512485-B21
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HPE iLO Advanced Electronic License with Support on iLO Licensed Features
HPE iLO Advanced Electronic License with 3yr Support on iLO Licensed Features
#E6U64ABE
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HPE iLO Advanced Electronic License with 1yr Support on iLO Licensed Features
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Microsoft Windows Server 2025 ROK AMS Software
Microsoft Windows Server 2025 (16-Core) Standard ROK AMS Software
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Microsoft Windows Server 2025 (16-Core) Datacenter ROK AMS Software
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Microsoft Windows Server 2025 (10-Core) Essentials ROK AMS Software
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HPE Internal Storage Options

Compatible with HPE ProLiant ML350 Gen11 (Base SKU P69313-005).

HPE 480GB SATA Mixed Use (2.5-inch) SSD
#P40502-B21
Our Price: Request a Quote
HPE 2.4TB SAS 10K (2.5-inch) 512E HDD
#P28352-B21
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HPE 1.2TB SAS 10K (2.5-inch) HDD
#P28586-B21
Our Price: Request a Quote
HPE Processor and Memory Options

Compatible with HPE ProLiant ML350 Gen11 (Base SKU P69313-005).

Intel Xeon Gold 5416S Processor for HPE
#P49653-B21
Our Price: Request a Quote
HPE 32GB DDR5-4800 Memory
#P43328-B21
Our Price: Request a Quote